Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.
RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells.
RANK has been shown to interact with TRAF6, TRAF5, TRAF1, TRAF2 and TRAF3.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.